National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- PRIMATE MODELS TO EVALUATE HIV PREVENTION & THERAPEUTIC STRATEGIES SOL NIH-NIAID-DAIDS-01-17 DUE 111300 POC Ross Kelley, Contracting Officer, (301) 402-2234 E-Mail address: rkelley@niaid.nih.gov The Targeted Interventions Branch, Division of Acquired Immunodeficiency Disease Syndrome, National Institute of Allergy and Infectious Diseases (NIAID) has a requirement for the evaluation of potential therapies for HIV infection and non-vaccine strategies for preventing sexual transmission of HIV. The Contractors will be responsible for (1) evaluating therapeutic and prevention strategies against SIV/SHIV in cell-based assays; (2) evaluating therapeutic and prevention strategies in vivo in acute and chronic SIV/SHIV disease models using predominantly a mucosal challenge route; and (3) optimizing/modifying the in vitro and in vivo models to enhance their use in these and other applications. In vivo evaluations include broad spectrum assessment of viral and immunologic parameters, measures of toxicity, and limited pharmacokinetics. The current contract utilizes up to 90 non-human primates (NHP) per year in the performance of contract work. A minimum capacity of 90 NHP per year is needed. It is anticipated that two to three (2-3) cost reimbursement, completion type contracts will be awarded for a minimum period of five (5) years beginning approximately September 1, 2001, and will contain options for two additional years. RFP NIH-NIAID-DAIDS-01-17 will be available electronically on or about June 19, 2000, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page by using the following electronic address and instructions: NIAID/CMB Home Page (via the WWW): Use http://www.niaid.nih.gov/contract to access the NIAID/CMB Home Page. Once at the NIAID/CMB Home Page, click on the "RFPs" link and then click on "RFP NIH-NIAID-DAIDS-01-17." Please note that the RFP for this acquisition has been revised to include only the Work Statement, Deliverable and Reporting Requirements, Special Requirements and Mandatory Qualification, if any, the Technical Evaluation Criteria, and the Specific RFP Instructions and Provisions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on November 13, 2000. Any responsible Offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. Posted 06/05/00 (W-SN461482). (0157)

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