Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550

A -- LAWRENCE LIVERMORE NATIONAL LABORATORY IS SEEKING INDUSTRIAL PARTNERS TO COMMERCIALIZE AND LICENSE A TECHNOLOGY FOR THE DETECTION OF CHOLESTEROL MICROCTYSTALS (MICROLITHIASIS) IN HUMAN BILE. SOL CBD00-028 DUE 070700 POC Industrial Partnerships and Commercialization (925) 423-3139 WEB: Click here to contact our website regarding your interest, http://www.llnl.gov/IPandC/op96/ERCPform.htm. The Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy is seeking industrial partners to commercialize and license a technology for the detection of cholesterol microctystals (microlithiasis) in human bile. This device is designed for detection of cholesterol microcrystals in bile. Bile samples are routinely withdrawn from pancreatitis patients undergoing endoscopy (endoscopic retrograde cholangiopancreatography, or ERCP). The precise link between microlithiasis and ideopathic pancreatitis is not known, but a significant fraction of the patients who undergo either cholecystectomy (gallbladder removal) or endoscopic sphincterotomy do not have recurring symptoms. Normally, the patient is discharged from the hospital and the bile is submitted for laboratory analysis. In some cases, a sample that tests positive for microlithiasis is an indication for further intervention such as ERCP or surgery. Such procedures subjectthe patient to additional inherent risks, and lead to significant additional costs that could in some cases be avoided if a microlithiasis diagnosis could be made intra-operatively during the initial ERCP. Thus the device is envisioned to reside in the endoscopy suite where a rapid assessment of a bile sample could be made during ERCP. The device could also be used for routine laboratory analysis of bile for microlithiasis, or for other micro-crystals, such as uric acid, in other fluids. This technology will be of interest to medical device companies, specifically companies that have a presence in the G.I. endoscopy or analytical medical device markets, and companies that manufacture hospital laboratory equipment. Licensees and collaborators are sought with technical and scientific expertise in the areas of endoscopes and other G.I. diagnostic instruments . Successful industrial partners will have an established history and consistent record of research and development and experience and expertise in endoscopy. THIS IS NOT A PROCUREMENT If you are interested in licensing this device, please contact our website at: http://www.llnl.gov/IPandC/op96/ERCPform.htm by July 7, 2000. Posted 06/06/00 (W-SN461958). (0158)

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