U.S. Environmental Protection Agency, Program Contract Service Center (3803R), 401 M Street, SW, Washington, DC 20460-0001

B -- AGGREGATE EXPOSURE ASSESSMENT USING NHEXAS DATA SOL PR-DC-00-01319 DUE 062800 POC Yvonne D. Stiso/Contract Specialist/stiso.yvonne@epa.gov E-MAIL: Click here to contact the Contract Specialist, stiso.yvonne@epa.gov. The Environmental Protection Agency under the Simplified Acquisition Procedures of FAR Part 13 intends to issue a sole source purchase order to Dr. Timothy Buckley, Johns Hopkins University. The EPA is FACNET certified. The SIC Code is 8731. NO PHONE CALLS WILL BE ACCEPTED. The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 6.302. Interested persons may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive proposals. However, all proposals received within fifteen days (thirty days if award is issued under an existing basic ordering agreement) after date of publication of this synopsis will be considered by the Government. A determination by the Government not to compete with this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information receivedwill normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Title: Aggregate Exposure Assessment Using NHEXAS Data BACKGROUND: Looking at chemicals and sources in isolation does not reflect actual patterns of exposure to chemicals in the environment. In reality, people can be exposed to many chemicals from a variety of sources, such as water, food, air, and dust. Exposure to chemicals from several different sources is often referred to as "multimedia," or multiple pathway, exposure. Different people also spend varying amounts of time indoors and outdoors or otherwise engage in activities that may have important impacts on their chemical exposure. More complete assessments of exposure should take into account multiple chemicals from various routes and sources. The National Human Exposure Assessment Survey (NHEXAS) Phase I investigated the feasibility to measure total human exposure to multiple chemicals on a community and regional scale. It focused on the exposure of people to environmental pollutants in their daily lives. To accomplish this, hundreds of subjects were recruited from several areas of the country to participate in this study. Researchers measured levels of chemicals in the air participants breathe; in food, drinking water, and other beverages; and in the soil and dust around their homes. Measurements were made of chemicals in biological samples (hair, blood, and urine) in some participants. Participants completed questionnaires to help identify possible sources of exposure to chemicals. The Agency anticipates that the information collected in NHEXAS will help individuals, communities, states, EPA, and other organizations understand the greatest health risks from various chemicals and decide whether steps to reduce those risks are needed. This project will investigate the ability to use NHEXAS data for aggregate exposure assessments. The data will be compiled into a SAS database. Data will be grouped according to exposure routes, sources, age classification, subpopulation characteristics, geographic locality, and socioeconomic demographics. Data will be analyzed to determine if it is complete and capable of being used for aggregate exposure assessments. Exposure factors will be identified. Assumptions and default values will be selected to substitute for missing data to the extent necessary to construct an aggregate exposure assessment using NHEXAS data. Posted 06/12/00 (W-SN463792). (0164)

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