National Institute of Environmental Health Sciences, Acquisitions Management Branch, 79 T.W. Alexander Drive, Building 4401 Research Commons, P.O. Box 12874, Research Triangle Park, NC 27709

66 -- OLIS RAPID-SCANNING SPECTROPHOTOMETRY SOL DLR00204 DUE 071000 POC Contract Point, Dee Lunney, Contracting Officer, (919)541-0387 The National Institute of Environmental Health Sciences intends to award a sole source purchase order to On-Line Instrument Systems (OLIS), pursuant to 41 U.S.C.253(c)(1) -- Only one responsible source and no other supplies or services will satisfy agency requirements. This procurement is for a Olis Rapid Scanning Spectrophotometry with analog temperature control module, closed cycle cooling box, shutter box incorporation, excitation monochromator shutter and on-site installation. The spectrophotometry system has the following required features: 1. Must include a double grating monochromator with a scan rate of 1,000 scans/second (typically, 230,000 nm per second or 1.4 x 10[7] nm/min) to be used in absorbance scanning; 2. Must include a double grating monochromator with a scan rate of 1,000 scans/second which can be used as a single grating emission monochromator by positioning of side-window photomultiplier tube in the mid-plane of the monochromator; 3. sample compartment must allow custom adaptation for using jacketed cuvettes, stopped-flow mixing system, cold tip cryogenic flask, and/or other required sample holder; 4. must support microsecond fixed wavelength detection at rates to 2 MHz (2 x 10[6] readings/second; 1.8 x 10 [8] readings/minute). Must also be capable of conventional speed scanning; ratings must be moved in synchrony for conventional slow scanning; 5. Software supplied with the instrument must include the "Simplex Method", a linear fitting procedure which is applicable to linear an non-linear problems using linear optimization of the parameters until some convergence crite-rior is met. (The Simplex Method differs from the widely known and widely used Levenberg-Marquardt and Gauss-Newton methods in that it does not use derivatives of the function with respect to the parameters, and thus, is much less prone to find false minima.) In addition, the software must include the exact "Matrix Exponential Solution" method in kinetic analysis, which is markedly more precise than numerical inte-gration methods and which does not have Runga-Kutta's stiffness. The software must also include data compression algorithms to reduce the size of the raw data files by 40 fold while losing non of the information. All responsible sources may respond by submitting a written narrative statement of capability to Dee Lunney at the above address for consideration by the agency. Response must include detailed technical information and other technical literature demonstrating the ability to meet these requirements. Responses shall also include itemized pricing that is sufficient to make a determination that competition is feasible. If no affirmative responses are received an order will be placed with On-Line Instrument Systems. The SIC Code/Size is 3826/500EM. This procurement is to be processed using Simplified Acquisition Procedures. See Note 1.***** Posted 06/22/00 (W-SN467467). (0174)

Loren Data Corp. http://www.ld.com (SYN# 0292 20000626\66-0010.SOL)