U.S. Environmental Protection Agency, Program Contract Service Center (3803R), 401 M Street, SW, Washington, DC 20460-0001

B -- INVESTIGATION TO MODEL PERCUTANEOUS ABSORPTION SOL PR-HQ-00-0428 DUE 072500 POC Gerald N. Alston 202-564-4771 E-MAIL: Click here to contact Gerald Alston via email, alston.gerald@epa.gov. This amendment corrects the inital submission which was transmitted yesterday, and was missing most of the Description in item 17. The U.S. EPA is contemplating a sole source award to the Colorado School of Mine, using the Simplified Acquisition Procedure for Investigation to Model Percutaneous Absorption. The purpose of this requirement is to identify fundamental relationships which permit calculations of scientifically acceptable approximations of the dose related flux of the chemicals not yet tested for percutaneous absorption using data contained in the Office of Pesticide Programs Zendzian Database. Using the assembled percutaneous absorption data and chemical characteristics data, develop computational procedures to estimate dermal absorption from pesticides. Develop the basis of mathematical models that fit these data such that these models can be applied to pesticide chemicals where no dermal absorption data exist. (1) Using percutaneous absorption data for the following (10) ten chemicals, Cyproconazole; Difenoconazole; Diniconazole; Epoxiconazole; Fenbuconazole; Fluqinconazole; Hexaconazole; Propiconazole; Tetraconazole and Uniconazole, compile a list of chemical characteristics and solubility data from the Colorado School of Mines database and from scientific literature to combine with the dermal absorption data provided by EPA. (2) Sort data complied by solution or suspension, dose related skin residue for selected exposure duration, and dose related flux for the selected exposure durations. Standardize these data by reporting all doses, residue and fluxes in consistent units of mass and molarity. (3) Analyze the standardized data for fundamental relationships with chemical property data, and identify and characterize them using mathematical equations. (4) Develop and test preliminary mathematical models that describe and predict the experimental data based on physicochemical parameters. (5) Design a database format that combines relevant features of the preliminary mathematical model that can be used to conduct more rigorous investigations to predict the dermal absorption behavior of chemicals. (6) Write the results of these investigations in the form of a journal article for publication. (7) Address how the use of secondary data will be handled to carry out this requirement. All responsible offeror's are encouraged to demonstrate their capabilities to complete this requirement along with their proposals. See Note 22.***** Posted 06/22/00 (W-SN467367). (0174)

Loren Data Corp. http://www.ld.com (SYN# 0011 20000626\B-0002.SOL)