National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

B -- BIOMEDICAL RESEARCH SERVICES SOL NCI-RFQ00139-NQ DUE 071000 POC Cynthia Brown, Purchasing Agent (301)402-4509 The National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Clinical Sciences plans to procure Biomedical research services from BTR Inc., 11300 Corobon Lane, Great Falls, VA 22066. The National Cancer Institute utilizes fluorescent in-situ hybridization (FISH) for the elucidation of chromosomal aberrations in cancer cells, fluorescent microscopes and digital imaging. In addition, the Cancer Chromosome Aberration Project requires precision optical equipment for the high resolution mapping of 5000 BAC clones distributed over the entire human chromosome complement. The Division of Clinical Sciences requires the services of a contractor with specialized knowledge and training in the management of Molecular Biology and Cytogenetics, Flourescent in-situ Hybridization (FISH) research laboratories to organize and manage the laboratory. The contractor will be required to develope and utilize a tracking database to take physical inventory on a weekly, as needed basis of all chemicals, disposables and supplies required by the FISH laboratory. The FISH lab depends on these services for its ongoing operation in developing and applying fluorescent in-situ hybridization based methods for the early diagnosis of cancer cells and for the detection of chromosomal aberrations in mouse models of human cancer. Government owned property of laboratory computers and software computers will be provided. BTR is the only known source to the NCI that is familiar with both the intricacies of the research and unique features of the software programs used in the lab management process. BRT has developed a proprietary database program to track the supplies chemical and reagents that are used in the laboratory. The knowledge of the BTR staff extends to such broad areas as understanding; (1) the intricacies of the in-situ hybridization and the specific requirements of the fluorescent labeling process and polymerase chain reaction (PCR) techniques; (2) the challenges to maintaining tissue culture facilities; (3) mastery of software programs and technical expertise to do technical writing and editing; and (4) the NIH procurement process. BTR has intimate knowledge and access to the computer hardware and software that is required to operate the programs. This is not a solicitation for competitive quotations. However, if any interested party believes it can provide the above service, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office on July 10, 2000 by 2:00 p.m. EST (local Washington, DC time). For further information please contact Cynthia Brown, Purchasing Agent, (301) 402-4509. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls or faxes will be accepted. Reference solicitation number NCI-RFQ00139-NQ Posted 06/22/00 (W-SN467439). (0174)

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