National Institutes of Health, Office of Procurement Management, 6011 Executive Blvd., Rockville, Maryland 20892-7260

66 -- SPECTROMETER -- STOPPED FLOW POC Sheri Custer, Contracting Officer on 301-402-3065 or Edward Wilgus, Chief, Acquisitions Branch B on 301-402-3070 MODIFICATION OF SPECIFICATIONS OF A PREVIOUS ANNOUNCEMENT: Under authority of U.S.C. 253(c)(1), FAR 6.302-1 the National Institutes of Health (NIH), Bethesda, Maryland intends to negotiate a contract with Applied Photophysics Ltd., 203-205 Kingston Rd., Leatherhead, Surrey KT227PB, England. Any response must be received in writing within fifteen (15) business days from the published date of this notice. The intended procurement will be classified under SIC 3826, Laboratory Analytical Instruments, with a size standard of 500 employees. This requirement is for a Spectrometer system. The contractor shall furnish, install and provide training. This system shall include, but not be limited to, the following performance characteristics, features, and pertain to the following components: (1) Pneumatic Syringe Drive: The stopped-flow system shall use pneumatic drives for mixing syringes such that there is no error in mixing rates. (2) Time Resolution of Analog-to-Digital-Converter: The minimum analog-to-digital conversion time shall be no greater than 10 microsecond or the maximum analog-to-digital conversion rate shall be no less than 100,000 Hz. (3) Minimum Wavelength Step Size of Monochromator: In the equilibrium mode, the wavelength resolution shall be no greater than 0.1 nm for a single step of the double grating monochromator. (4) Spectral Range: The usable ultraviolet range of the instrument shall extend down to at least 180 nm and the near infrared range shall extend to at least 900nm. (5) Repeatability: The repeatability of optical density measurements shall be at least +/- 0.001 OD for both equilibrium and kinetic measurements over the entire useful spectral range, of 180 to 900 nm. (6) Multiple Wavelengths: In the stopped-flow mode the instrument shall be capable of acquiring any of the three types of spectral data at multiple user-specified wavelengths in a single computer-controlled operation. (7) Global Analysis: The instrument shall include programs for analyzing all forms of data (equilibrium and kinetic) as an integral component of the basic operation software. The analysis software shall include global analysis of multi-wavelength data with singular value decomposition and reaction simulation capability. (8) Logarithmic Time Base: The instrument shall be capable of acquiring spectral data using a user-specified logarithmic time base. (9) Noise-Time Correlation: The instrument shall be capable of performing noise-time correlation analysis and indicating the number of scans needed to achieve a user-specified signal-to-noise level. (10) Instrument Setup: The instrument shall be capable of automatic setup of all computer-controlled acquisition parameters to match those of a stored data file. (11) Analysis Software: The analysis software shall include reaction simulation capability. (12) Time-Resolved Flash Photometer: The instrument shall be capable of being used as a time-resolved flash photometer for simultaneous absorbance and fluorescence detection. (13) Automatic Set-Up of Instrument: The instrumentshall be capable of being automatically set to all computer-controlled acquisition parameters to match those of a stored data file. (14) Measurement Modes: In the stopped-flow mode, the instrument shall be capable of simultaneously acquiring fluorescence data as well as either circular diochroism or absorbance data. (15) Infrared Range: The useable infrared range shall extend to no less than 900 nm. (16) Warranty: The instrument shall come with a minimum 12 (twelve) month warranty for parts and labor, to assure that the instrument meets the salient specifications herein during the warranty period. It is the Government's belief that these requirements may only be met by Applied Photophysics, Ltd. This is not a formal solicitation, however, concerns are invited to submit capability statements in an original plus two (2) copies no later than fifteen (15) business days from the date of this announcement. Concerns that respond to this synopsis shall furnish concise responses directed specifically to the requirements mentioned above Sources demonstrating the capability to accomplish the above shall supply pertinent information in sufficient detail to demonstrate their ability to perform. Written responses shall include complete description of the system to be provided, containing sufficient technical information to permit agency analysis to establish a bona fide capability to meet the stated requirements as listed above. Respondents will not be notified of the evaluation results. THIS IS NOT A REQUEST FOR PROPOSAL (RFP). Capability Statements: (a) If mailing your capabilities through the U.S. Postal Service use the following address: National Institutes of Health, Office of Procurement Management, OA, 6011 Executive Blvd., Room 529Q, ATTN: Sheri Custer, Bethesda, MD 20892-7663. (b) If hand delivering, or using a courier service such as: UPS, Federal Express, etc., USE THE FOLLOWING City, State, and Zip Code: ROCKVILLE, MD 20852. Responses by Facsimile (FAX) will not be accepted. See NOTE: 22 Not withstanding the forty-five (45) day notice for receipt of capability statements all Capabilities must be received within fifteen (15) days from publication in the CBD. Posted 07/11/00 (W-SN473549). (0193)

Loren Data Corp. http://www.ld.com (SYN# 0318 20000713\66-0008.SOL)

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