National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS IN LABORATORY ANIMALS -- ANDROSTENEDIONE, GOLDENSEAL, MILK THISTLE, THUJONE, AND CHROMIUM PICOLINATE SOL NIH-ES-00-28 DUE 093000 POC Jacqueline A. Osgood, Contract Specialist, (919) 541-7596, Donald A. Gula, Contracting Officer, (919) 541-0423 WEB: Click here for a streamlined copy of the RFP, http://www.niehs.nih.gov/dert/rcb/rfp.htm. E-MAIL: click here to e-mail the Contract Specialist, osgood@niehs.nih.gov. The purpose of this contract is to evaluate the toxicologic and carcinogenic potential of selected chemicals in laboratory animals used as dietary supplements and/or herbal medicines. This project include 90-day and 2-year studies of chromium picolinate, goldenseal, milk thistle, thujone and androstenedione. The base contract award shall consist of those work activities associated with determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, any health and safety concerns that must be addressed before study start, and other aspects specifically included in Phase 1 for Task 1 (androstenedione, Task 2 (goldenseal), Task 3 (milk thistle), Task 4 (thujone), and Task 5 (chromium picolinate). The Government may, pending the availability of funds exercise options for: 90-day study androstenedione, a two-year study of androstenedione (Task 1); 90-day study of goldenseal, a two-year study of goldenseal (Task 2); 90-day study of milk thistle, a two-year study of milk thistle (Task 3); 90-day study of thujone, two-year study of thujone (Task 4); and 90-day study of chromium picolineate, two-year study of chromium picolinate (Task 5). These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxicologic and Carcinogenic Potential of Selected Chemicals in Laboratory Animals for the National Toxicology Program (NTP) dated June 2000. Award of one cost-reimbursement completion contract on June 1, 2001 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 1,400 labor hours for the base contract and 127,250 labor hours for all options. The estimated period of performance is approximately 52 months. Interested organizations should request either a streamlined or full RFP package by written, telephonic ((919) 541-7596), or telefax request ((919-541-2712). If no selection is made, a streamlined version of the RFP will be provided, which will include only the Statement of Work, deliverables and reporting requirements, any special requirements, mandatory qualifications, and technical evaluation criteria. After examination of the streamlined RFP, any organization interested in responding to this RFP must request the full RFP package. A copy of the streamlined and full RFP (with Statement of Work only) will be available after the release date on the Internet at http://www.niehs.nih/gov/dert/rcb/rfp.htm. Those individuals who wish to access the on-line version should follow the instructions provided in the on-line solicitation package. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is July 30, 2000 with proposals due September 30, 2000. Posted 07/13/00 (W-SN474374). (0195)

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