COMMERCE BUSINESS DAILY ISSUE OF JULY 25,2000 PSA#2649 National Institute for Occupational Safety and Health, PO Box 6495,
Cincinnati, OH 45206 B -- DEVELOP A BIOLOGICALLY-BASED MATHEMATICAL MODEL SOL RFQ 00-06 DUE
082800 POC Phyllis Schweickart, 513/533-8185 The National Institute for
Occupational Safety and Health, Cincinnati, Ohio has a requirement for
a biologically-based mathematical model describing the clearance and
retention of chrysotile asbestos fibers in rodent lungs, and to
determine the dose-metric(s) that predict disease response. The results
of this kinetic modeling will provide a basis for evaluating
concordance with human exposure, dose, and response data for chrysotile
asbestos (in a separate NIOSH project; not included in this contract).
This information will be used in risk assessment of occupational
exposure to fibers. The tasks to be accomplished include: (1) a study
protocol, including a complete description of the proposed methodology
for: (a) quantifying the exposure-dose and the dose-response
relationships, (b) calibrating and validating the biomathematical
exposure-dose model, (c) assessing the uncertainty in model structure
and parameter values, (d) determining sensitivity of the model output
to alternative assumptions; (e) extrapolating the rodent dosimetry
model to predict fiber lung burdens in humans with occupational
exposures, and (f) predicting malignant and nonmalignant disease risk
in humans from the rodent data; and (2) development of a
biologically-based dosimetry model, including (a) a structure that
reflects the major biological compartments influencing disposition of
fibers in the lungs, insofar as reasonable, (b) an evaluation of
variability, uncertainty, and sensitivity of the model and parameter
values, and (c) extrapolation of model to predict fiber lung burdens in
humans with occupational exposures to chrysotile; (3) quantification of
the dose-response relationship in rats for chrysotile fiber burdens and
malignant and nonmalignant diseases and risk predictions in humans,
including (a) using existing statistical or biological models in the
literature (e.g., logistic, probit, multistage, 2-stage clonal
expansion model, or time-to-tumor models) to model the rat data, and
(b) predicting malignant and nonmalignant lung diseases in humans with
fiber burdens predicted in preceding task; and (4) final report,
including abstract, introduction, methods, results, discussion,
references, and appendixes (including final programs and data files
used for the models). The successful awardee must have personnel with
education, work experience, and publications in the areas of
biologically-based mathematical modeling and statistical modeling. The
successful awardee must also provide documentation on the availability
of, or access to, adequate data for the successful completion of this
procurement. These data may consist of existing published or
unpublished experimental data in laboratory rats or hamsters exposed by
chronic inhalation to respirable chrysotile asbestos. A more detailed
description of the scope of work and minimum qualifications for
personnel and data are provided in the RFQ. Requests for the Request
for Quotation must be in writing only. You may FAX your request to the
following number: (513) 533-8283, Attn: Phyllis Schweickart. All
responsible businesses may submit a written quotation which, if
received timely, will be considered by the agency. Simplified
Acquisition Procedures will be utilized for this purchase. The
anticipated issuance date of this RFQ is August 7, 2000. Posted
07/21/00 (W-SN477594). (0203) Loren Data Corp. http://www.ld.com (SYN# 0015 20000725\B-0005.SOL)
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