National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- COORDINATING CENTER FOR THE AFRICA AMERICA DIABETES MELLITUS STUDY SOL N01-HG-85432 POC Contact Velvet M. Torain, Contract Specialist, 919/541-0400 WEB: None, None. E-MAIL: None, None. The Government intends to negotiate a modification to the statement of work for the contract with Howard University College of Medicine. The contractor shall be required to (1) enroll five additional family members of the affected sib-pairs for a total of 2000 persons. Each West African site shall be required to enroll 400 persons. Offspring participants shall be above the age of 14; (2) perform high resolution mapping and candidate gene analysis. A core set of candidate genes for type 2 diabetes shall be analyzed on all samples. Allele frequencies and haplotype analyses shall be performed on the candidate genes. Single Nucleotide Polymorphisms (SNP) technologies and linkage disequilibrium mapping shall be used by the NHGC Molecular genetics Laboratory to generate databases for functional mutation analyses in candidate genes; (3) perform statistical genetic analyses and bioinformatics. Using the broadly applicable distributions, and the classification and regression trees (CART) method for screening large numbers of markers and other risk factors, modeling and distribution and familial correlations in age-of-onset; Segregation and linkage analyses; Implementation in the software package, G.E.Ms, which is designed to be user-friendly and portable across common computing platforms. The changes to the statement of work will not require an extension of the expiration date of the contract. The current employees will increase their level of effort. See Numbered Notes 22 and 26. Posted 07/25/00 (W-SN478524). (0207)

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