National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

65 -- INTERVENTIONAL CARDIAC MAGNETIC RESONANCE IMAGING SYSTEM SOL NHLBI-HL-P-00-641 DUE 090100 POC Kathleen Jarboe, Contracting Officer, (301) 435-0364 This is a synopsis for commercial items, prepared in accordance with the format in FAR subpart 12.6, as supplemented with additional information included in this notice. Proposals are being requested and a written solicitation will be issued. The Cardiology Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute (CB, DIR, NHLBI) of the National Institutes of Health (NIH) has a requirement to obtain one (1) 1.5 Tesla Interventional Cardiac Magnetic Resonance Imaging System for the study of interventional techniques in cardiovascular disease. Specifically, the Contractor shall deliver, install, and maintain a 1.5 Tesla Interventional Cardiac Magnetic Resonance Imaging System with the following specifications: 1) Magnet/Magnetic Field Shims -- Minimum field strength shall be 1.5 Tesla; Magnetic field shielding is essential; Field homogeneity 0.1 ppm over 20cm DSV; 2) Gradients -- Shall provide a maximum gradient strength of at least 40 mTlm; Shall be designed using state-of-the-art technologies with regard to reducing short and long term magnetic field eddy current effects during gradient switching; Slew rate maximum of at least 120 Tlmlsec. Overall clear bore of system, including radio frequency body coil shall be 60 cm or greater; Detailed diagrams of the magnet/gradient/body coil geometry need to be provided to evaluate the use of this system for interventional exams; 3) Console -- Shall have 500 KHz (full bandwidth) digital receivers (4 or greater channel phased-array minimum); 20 frames per second real-time imaging (this means a 128 x 128 acq matrix, 256 x 256 display, 4-channel acquisition, displayed in real-time at 20 fps) at 30 cm field of view and at 15 cm field of view; Echo-Train readout specs -- For XRES=256, +/- 125 KHz bandwidth, ETL=8, ESP=1.3 ms, TR=13 ms, with all 4-channels operating simultaneously. For XRES=128, +/- 125 KHz bandwidth, ETL=16, ESP=0.7 ms, TR=14 ms, with all 4-channels operating simultaneously; Arbitrary waveform generation for rf and gradients; 4) Radiofrequency Coils -- Shall have a quadrature body coil capable of performing 180 degree magnetization flip angles within 3 msec in the human chest; Shall have multi-channel phase array detection system for the chest and peripheral vasculature to optimize signal to noise characteristics; Quadrature head coil; Phased array extremity coil for cardiac studies; Assorted surface coils for peripheral and cerebral vasculature studies; A large extremity array for peripheral vasculature studies; 5) General Considerations and Overall System Performance -- The following minimum requirements shall be met: a) Interventional MRI -- Occasionally, the system will be used in a continuous, real-time, fluoroscopic mode of imaging. It is anticipated that MR compatible needles and catheters will be used under MR guidance; therefore, controls for scan-plane adjustment and image display on multiple monitors shall be required in the scan room at a convenient location. Ideally there would be two in-room monitors, one for image scanning information, and one for image display. The patient table shall be easily controlled from within the magnet room. This system will be used in conjuction with a Philips BH5000 biplane fluoroscopy system, so the offeror shall propose a method for smooth patient movement between the MRI scanner and the fluoroscopy system; b) The system shall be capable of collecting state-of-the-art images from the human heart and peripheral vasculature; c) 2-D Myocardial function assessment -- Post-acquisition tools shall be capable of displaying simultaneously at least 16 digital video loops from up to 16 different imaging planes. Basic post-processing tools shall be capable of rapid evaluation of cardiac chamber volumes, ejection fraction, and myocardial mass. Velocity encoded phase contrast studies of myocardial blood flow shall meet the same physiological parameters as listed above. Myocardial tagging experiments shall be available in the software package. These experiments shall be capable of 1-D and 2-D tagging. The sequences shall support parallel plane saturation as an option; d) Myocardial functional imaging during stress -- Hardware and software shall be designed for functional stress testing of patients with coronary artery disease. Specifically, rapid functional imaging of the heart shall be accomplished in short breath holds (i.e. less than 8 seconds per imaging plane) and in non-breath-hold, non-gated mode. Software shall be flexible to allow imaging multiple locations of the heart at all levels of a multistage stress test. Displays shall allow side-by- side comparison of baseline and stress function; e)Myocardial perfusion imaging -- Hardware and software shall be capable of imaging multiple slices of the heart every hearbeat in a cardiac gated experiment capable of capturing an arbitrary number of consecutive heart beats during the first passage of gadolinium contrast from peripheral vein through the myocardial enhancement phase. Temporal resolution of these images shall be better than 125 msec, with spatial resolution of 2mm x 3mm; f) Safety monitoring -- The patient's heart rhythm, respiratory waveform, pulse oximetry waveform, oxygen saturation, and non-invasive blood pressure readings shall be available in both the magnet room and the control room. Mechanisms for rapidly obtaining a 12-lead ECG outside of the magnet shall be present; g) MR Angiography -- The system shall have hardware and software capable of performing 2-D and 3-D coronary angiography during breath holds. Similarly, the system shall be capable of 2-D and 3-D time of flight brain and peripheral angiography with a TE<2ms. These techniques shall maintain image resolution of approximately 1 mm x 1 mm; h) ECG gating -- Options for more than one gating algorithm shall be available. For example, an ECG gating algorithm might have amplitude detection, slope detection, or peak detection. The system shall be able to gate off the ECG, pulse oximeter, or respiratory monitor. There shall also be an external analog output for accessory devices to monitor the patient physiology; and 6) Instrument Maintenance and Research Technical Support -- Extended maintenance is anticipated for the proposed instruments for four (4) years after the warranty period has expired. It is anticipated that some modifications of hardware and software will be required. Therefore, the offeror shall include in their proposal a detailed plan on how these modifications will be made. This includes software support for pulse programming, scan control, and image processing/display as well as data transfer to third party platforms. It is anticipated that both hardware and software upgrades will be required for the instrument over the entire contract period of performance. The offeror shall outline the costs of upgrades in their proposal. The award of a firm, fixed-price type contract is anticipated. This requirement is not a set-aside. The applicable Standard Industrial Classification (SIC) is 3844, size standard 500 employees. The proposals may be due fifteen (15) calendar days from the publication date of this synopsis. Interested parties should submit a written request (via mail or facsimile transmission to (301) 480-3345 for a copy of the solicitation number NHLBI-HL-P-00-641 to the National Heart, Lung, and Blood Institute, Contracts Operations Branch, Procurement Section, Building RKL2, Room 6142, 6701 Rockledge Drive, Bethesda, Maryland 20892-7902, Attention: Kathleen Jarboe, Contracting Officer. All responsible sources may submit a proposal, which if timely received shall be considered by the Government. Posted 08/15/00 (W-SN486235). (0228)

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