National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- INSTRUMENTS & LABORATORY EQUIPMENT(MASS SPECTROMETER) SOL RFQ-NCI-00200 DUE 090500 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Gail Zois, Contracting Officer The National Cancer Insitute(NCI), Divisin of Clinical Sciences (DCS), Medicine Branch (MB), Cell and Cancer biology Department (CCBD), intends to procure on a sole-source basis, a Benchtop Mass Spectrometer, Model M@LDI, catalob #V-HTNR, From Micromass, Inc. This purchase encompasses a benchto MALDI-TOF mass spectrometer, a mass spectrometer work station, and ultra high throughput MALDI proteomics package, a biopolyer analysis software module and license, sequencing software module and license, acquisition and processing automation software and, other associated hardware/software. The critical point here is that Micromass has integrated and seamlessly linked operation of the equipment with Bio-Rad's, PDQuest gell imaging system so samples can be automatically tracked through the entire process. Requirement: shall be a benchtop, compact system with a MALID-TOF mass spectrometer; shall be controlled by a stable Windows NT data system; laser tuning, real time data selection, data acquisition, data processing database searching and reporting shall all be automatically controlled via the software. Data processing and database searching shall do the following in an automated fashion without user intervention; combine MS spectra (shall use spectrum from near point reference spot to check calibration); significantly enhance the signal to noise ratio of the spectra by simplifying the specturm to carbon 12 isotopes and deisotoping overlapping isotopic clusters; correct the mass assignment using the internal lock mass; and, collate and report results in an interactive browser. The spectrometer shall have reflectron optics with an effective path length of 2.3 meters; spectrometer shall have grounded "Time Lag Focusing" source (delayed exraction) optices with immersion lens focusing optimized for maximum ion transmission; system shall have an automated laser guidance system for optimization of the MALDI sample plate position; software shall auto-annotate gel spots with the appropriate protein assignments (allowing theuser to access and review data suppriting any individucal protein assignment by a simply point and click on a protein spot of interest; and, mass spec software shall be completely ingrated and compatible with BioRad's PDQuest gell imaging system so samples can be automatically tracked through the entire process. The Contrcator shall include a one year parts and labor warranty and unlimited telephone software support during the warrranty period at no additonal cost to the Government. Software maintenance releases/updates shall be provided upon request at no additonal cost to the government. Shall include installation and on-site trining at no additioanal cost to the Government. This is not a request for competitive quotation, however, if any interested party believes it can meet the aobve requirment, they may submit a statement of capabilities. Information furnished must be in writing and must contain sufficient detail, to allow NCI to determine if the party can meet the requirement. Capabiality statements must be received nt he Contracts Officey by 2:00 PM EST on 9/5/00. If you have any questions, please contact Cynthia Brown, Purchasing Agent on (301) 402-4509. A determination by the government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the pupose of determining whether to conduct a competitive procurement. Please reference solicitation number RFQ-NCI-00200. Posted 08/17/00 (W-SN487408). (0230)

Loren Data Corp. http://www.ld.com (SYN# 0280 20000821\66-0018.SOL)

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