A -- BIOMATERIALS FOR THE CENTRAL NERVOUSSYSTEM

Notice Date

October 31, 2000

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke, 6001 Executive Boulevard, Nueroscience Center Building, Suite 3287, MSC 9531, Bethesda, MD, 20892-9531

ZIP Code

20892-9531

Solicitation Number

NIH-NINDS-01-02

Response Due

February 17, 2001

Point of Contact

Kirkland Davis, Chief, Contracts Management Branch, Phone (301) 496-1813, Fax (301) 402-4225, Email kd17c@nih.gov

E-Mail Address

Kirkland Davis (kd17c@nih.gov)

Description

The Repair and Plasticity Cluster of the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, has a requirement for the research and development of a biocompatible matrix on the surface of implantable silicon microstructures that will improve the mechanical stability of the microelectrode-tissue interface and will provide a bridge between the microstructure and neurons, glia and related cells. Microelectrode arrays are being developed that are capable of stimulating or recording concurrently from many individual cells in the central nervous system. In acute settings stimulation or recordings can be routinely accomplished. Unfortunately, the techniques that are effective for acute recordings and stimulation do not generalize to the chronic recording environment. For dependable chronic recording or stimulation of specific cells, the interface between the microelectrode and target cells needs to be made more stable. This research effort will focus on achieving such stability through modification of the surface properties of microelectrode arrays. Personnel with expertise in materials science, neural prosthesis, biomaterials, neurobiology, extracellular matrix biology and biomechanics will be needed to perform this research. It is anticipated that one cost-reimbursement award may be made for a period of four years. Award is anticipated for July 2001. This is not a Request for Proposals (RFP). RFP No. NIH-NINDS-01-02 WILL BE ISSUED ELECTRONICALLY AND WILL BE AVAILABLE at the following website (http://www.ninds.nih.gov/funding/currentrfps.htm) 15 or more calendar days after the publication date of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENT WILL BE PROVIDED. All responsible sources may submit a proposal, which shall be considered by the agency. Refer to numbered note

Web Link

Visit this URL for the latest information about this (http://www2.eps.gov/cgi-bin/WebObjects/EPS?ACode=P&ProjID=NIH-NINDS-01-02&LocID=3171)

Record

Loren Data Corp. 20001102/ASOL002.HTM (D-305 SN5055T6)