A -- STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS VIA INHALATION

Notice Date

May 30, 2001

Contracting Office

National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

ZIP Code

27709

Solicitation Number

NIH-ES-01-13!!

Response Due

August 10, 2001

Point of Contact

Point of Contact to request RFP only: Ms. Melissa Pittman (919)316-4625, Contracting Officer: Ms. Marilyn B. Whaley, 919/541-0416!!

Description

The NIEHS is soliciting offers for a contract to evaluate the toxicologic and carcinogenic potential of selected chemicals to which humans are exposed in the workplace or at home via inhalation. This project includes 14-day, 90-day, and 2-year studies of 1-Bromopropane, Cobalt metal, Diethylamine, and Triethylamine. Multiple studies shall be conducted concurrently. The base contract shall consist of Phase 1 for all four chemicals to include those work activities associated with identity and purity determination of the bulk chemical, development of generation and monitoring methods, health and safety concerns, and the conduct of the 14-day study. Upon successful completion of Phase 1, the Government may unilaterally exercise options for the conduct of 90-day studies specified as Phase 2. Upon successful completion of Phase 2, the Government may unilaterally exercise options for the conduct of 2-year studies specified as Phase 3. These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program dated September 2000. Offerors shall have a working laboratory conducting studies by the required route of administration in place by the date of proposal submission. The Principal Investigator, Engineer/Exposure Specialist, Toxicologist, Chemist, Veterinarian, Health and Safety Officer and Quality Assurance Unit Officer shall be employees of the contract laboratory (i.e., not consultants or subcontractors). The daily interaction and constant coordination of efforts needed amongst these discipline areas throughout the in-life portion of the studies makes it critical that they be physically and organizationally together. Award of one cost-reimbursement, completion type contract on March 29, 2002 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 13,405 labor hours for the base contract and 135,260 labor hours for all options. The estimated period of performance is approximately nine months for the base contract and four years seven months if all options are exercised. Interested organizations should telefax a request for RFP NIH-ES-01-13 to the attention of Ms. Melissa Pittman, Procurement Technician at (919) 541-2712 or send an e-mail request to pittman@niehs.nih.gov. The electronic version of the CBD synopsis is available on the Internet at: http://www.niehs.nih.gov/dert/rcb/rfp.htm . An electronic copy of the RFP (without the NTP Specifications) will be posted to this site on or about June 18, 2001. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is June 18, 2001 with proposals due August 10, 2001.*****

Record

Loren Data Corp. 20010601/ASOL009.HTM (W-149 SN50N336)