66 -- EXCITATION/EMISSION FLUORESCENCE SYSTEM

Notice Date

July 3, 2001

Contracting Office

Department of Health and Human Services, Food and Drug Administration, Division of Contracts and Procurement Management, Office of Facilities, Acquisitions, and Central Svcs 5600 Fishers Lane, HFA-511, Rockville, MD, 20857

ZIP Code

20857

Solicitation Number

Reference-Number-A230014

Response Due

July 17, 2001

Point of Contact

Ida Cofield, Contract Specialist, Phone (301) 827-7156, Fax (301) 827-7151, Email icofield@oc.fda.gov

Description

This is a combined synopsis /solicitation for commercial items or services prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; and a written solicitation will not be issued. This solicitation is issued as a Request for Quote (RFQ )No. A230014). The solicitation clauses and provisions are those in effect through Federal Acquisition Circular 97-27. The Standard Industrial Classification (SIC) Code for this acquisition is 3827 and the NAICS Code is 334516. The Food and Drug Administration (FDA) is issuing a RFQ on the following: A system for measuring the fluorescence of tissue and phantoms. All components shall be computer-controllable, allowing fully automated acquisition of the excitation/emission matrix (EEM) of the sample. Fiber optic coupling of excitation and detection arms is compatible with user-design probes (SMA on source side, linear fiber arrays in stainless ferrules up to 10 mm at detector side). Integrated computer control of all system parameters enables rapid acquisition of a full matrix of excitation/emission data while minimizing sample optical and environmental exposure. The source sub-system is comprised of a xenon light source and a monochromator. The monochromator contains an order-sorting filter wheel and entrance slit shutter and motorized slit (all computer-controlled). A computer controllable grating turret allows for both automated scanning and selection of one of three gratings. An adapter on the exit of the monochromator efficiently couples the output into an optic fiber. The detector sub-system consists of an imaging spectrograph and CCD detector. The imaging spectrograph contains internal filter wheel and triple grating turret and motorized slits- all are computer controlled. The end exit port is fitted with a multi-channel detector flange with motorized port selection. A fiber adapter matches the numerical aperture of the user-designed fiber array to the acceptance angle (f/number) of the spectrograph. The detector is a spectroscopic format array optimized for high sensitivity, high signal-to-noise operation over the UV-VIS-NIR spectral range. The detector is computer-controllable for rapid multi-stripe spectral acquisition. Performance requirements shall be: Monochromator Czerny-Turner design, computer-controlled entrance and exits slits, entrance shutter, triple-grating turret and six-position filter wheel. Imaging optics to efficiently couple output to optical fiber. Three gratings (150 G/mm, 300 nm blaze; 300 G/mm, 300 nm blaze; 300 G mm, 500 nm blaze). Focal length 300 mm. Resolution 0.1 nm (or better). Scan range 0 to 1400 nm (or better). Accuracy plus/minus 0.2nm (or better). Repeatability plus/minus 0.05nm (or better). The Spectrograph shall have imaging Czerny-Turner design with aspheric mirrors. Computer controlled entrance and exit slits, entrance shutter, triple grating turret and six position filter wheel. Multi channel detector adapter on end exit port. Motorized port selection mirror. Image optics to image fiber array onto entrance focal plane. Three gratings (150 G/mm, 300 nm blaze; 300 G/mm, 300 nm blaze; 300 G/mm, 500 nm blaze). Focal length 300 nm. Focal plane size 27 x 14 mm (w x h). Resolution 0.1 nm (or better) Scan range 0 to 1400 nm (or better). Accuracy plus minus 0.2 nm (or better). Repeatability plus/minus 0.05nm (or better). Light source shall have 75 W Xe light source with continuum from 190 to 750 nm. Includes housing coupling flange to monochromator & power supply. Detector shall have UV enhanced, back- illuminated, thermoelectrically-cooled camera head. Dual read out amplifiers: low noise and high capacity modes (software selectable); sealed window/detector housing (lifetime temperature guarantee). Camera controller with dual A/D converter-16 bit, 100 kHz and 16 bit, 1 MHz. PCI interface card with cabling; dedicated, laptop/docking station based computer/controller. Real time acquisition software for control of entire system-detector, monochromator and spectrograph including internal filter wheels, shutters and slits. Array format 1340 x 400 pixels; 20 x 20 um pixels. Array area 26.8 x 8.0 mm. Register well capacity greater than 800,000 electrons in high capacity mode. System read noise less than 5 electrons rms at 100 kHz digitization, less than 10 electrons rms at 1 MHz digitization. Dynamic range 16 bits. Quantum efficiency greater than 35 per cent at 200 nm, peak of greater than 90 per cent at 550 nm; greater than 30 per cent at 950 nm. Scan rate 100 kHz or 1 MHz. Spectral rate: 40 Hz with full vertical binning at 100 kHz, 75 Hz with full vertical binning at 1 MHz. Data acquisition time less than 200 ms (multi stripe binning; 10 pixel stripes that alternate read and ignored for a total of 10 read stripes at 100 kHz digitization). Dark current less than 0.05 electron/photon/sec at minus 50 degree C. Operating temperature minus 45 degree C under ambient conditions. The following FAR Clauses shall apply to this solicitation: 52.212-1 Instructions to Offerors ? Commercial, 52.212-4 Contract Terms and Conditions Electronic Funds Transfer. All responsible sources that can provide and meet the above requirement shall submit written quotations by mail or fax 301/827-7039. Evaluation/Award will be based on the technically acceptable quote that offers the best value to the Government. Quotes submitted in response to this solicitation shall be submitted by July 17, 2001, 4:00 P.M Eastern Daylight Savings Time to the above referenced address or fax 301/827-7039. FAR provisions can be found at the following website: http://www.arnet.gov

Web Link

Visit this URL for the latest information about this (http://www.eps.gov/spg/HHS/FDA/DCPM/Reference-Number-A230014/listin g.html)

Record

Loren Data Corp. 20010706/66SOL013.HTM (D-184 SN50Q861)