A -- GENETIC RESOURCE CENTER

Notice Date

July 13, 2001

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke, 6001 Executive Boulevard, Neuroscience Center, Suite 3287, MSC 9531, Bethesda, MD, 20892-9531

ZIP Code

20892-9531

Solicitation Number

RFI-NS-01-006

Response Due

August 13, 2001

Point of Contact

Patricia Denney, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, Email pd22n@nih.gov

Description

The National Institute for Neurological Disorders and Stroke (NINDS) is considering issuing a contract for a National Repository for the study of Human Genetic Disorders. The institute is attempting to identify competent sources to receive, p rocess, distribute, and track blood samples for the creation of cell lines and DNA and the accompanying data of participants in gene discovery research, while protecting participants confidentiality. Background Genetic studies of neurological disorders are increasing in number and complexity. Discovery of disease related genes requi res a large number of samples, which is difficult to obtain for the typical investigator. The National Institute of Neurolo gical Diseases and Stroke (NINDS) at the National Institutes of Health (NIH) is interested in establishing a repository whi ch will allow storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources impo rtant to research into genetic factors in Neurological diseases. Information Requested: Information in the following areas will aid in the design of the solicitation for a repository facil ity. We ask that interested organizations identify critical criteria to include in the solicitation and describe their capab ilities to meet these criteria. Information presented need not be limited to these areas. 1. Ability to receive blood or ti ssue samples from researchers across the nation. 2. An ability to insure that samples were collected under IRB approved pro tocols. 3. The ability to perform DNA and cell line preparation and storage, and to assure quality control. 4. A means of ma sking individual identities to insure confidentiality. 5. An ability to distribute samples. 6. Maintain a database of accomp anying data for each sample. 7. A safe and effective method for distribution of samples 8. Determination and cataloguing of charges to investigators requesting samples. 9. Development and maintenance of a website containing. (a) general information regarding the submission and requesting of samples including diagnostic checklists; (b) information regarding samples available, including diagnosis, number of affected members in which generations total (pedigree); (c) information regarding number of samples from that kindred, if such exists, in the repository; (d) the number of times the sample has been shared, five papers published in which samples have been used; (e) a list of researchers who have submitted samples to date. 10. Report to the NINDS Project and Contracting Officers on a regular basis regarding the above activities. 11. Develop responses to changes in needs of the repository as the field changes, according to the specifications of the Project and Contracting Officers. This Request for Information (RFI) is for information and planning purposes only and shall not be construed as a solicitatio n or as an obligation on the part of the Government. The Government does not intend to award a contract on the basis of resp onses nor otherwise pay for the preparation of any information submitted or the Government?s use of such information. Acknow ledgment of receipt of responses will not be made, nor will respondents be notified of the Government?s evaluation of the in formation received. However, should such a requirement materialize, no basis for claims against the Government shall arise a s a result of a response to this request for information or the Government?s use of such information as either part of our e valuation process or in developing specifications for any subsequent requirement. Responses will be held in a confidential m anner. Any proprietary information should be so marked. All respondents are asked to indicate the type and size of your business or organization, e.g., Large Business, Small Busine ss, Hubzone Small Business, Small Disadvantaged Business, Women-Owned Business, 8(a), Historically Black College or Universi ty/Minority Institution (HBCU/MI), educational institution, profit/non-profit hospital, or other non-profit organization. Responses should be identified with RFI No. NS-01-006, and are due by August 13, 2001. Please submit three (3) copies of you r response, with a maximum number of five pages, to Patricia Denney, Contracting Officer, Contracts Management Branch, Natio nal Institute of Neurological Disorders and Stroke, NIH, 6001 Executive Boulevard, Room 3282, Bethesda, MD 20892-9531 (For F edex or courier, use: Rockville, MD 20852). Email responses will also be accepted at pd22n@nih.gov.

Web Link

Visit this URL for the latest information about this (http://www.eps.gov/spg/HHS/NIH/NINDS/RFI-NS-01-006/listing.html)

Record

Loren Data Corp. 20010717/ASOL011.HTM (A-194 SN50R809)