NIDDK DATA AND BIOSAMPLE REPOSITORY

Notice Date

October 11, 2001

Contracting Office

National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases, Acquition Management Branch, 2 Democracy Plaza, Room 780, 6707 Democracy Blvd. MSC 5455, Bethesda, Maryland 20892-5455

ZIP Code

20892-5455

Description

NIDDK Data and Biosample Repository Request for Information Purpose of Request: This announcement is for the request for comments and suggestions on the draft potential list of tasks that is located at http:// http://www.niddk.nih.gov/fund/repositories/tasklist.htm. Background The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) has determined a need to set up a central NIDDK repository for biosamplesand data collected in large, multi-site studies. Having a central repository will expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study. At a minimum, this repository will collect data and samples from studies that have been completed. In addition, we seek comment on feasibility of making the repository serve as a processing and analysis facility for samples that will be collected in ongoing and new studies. Finally, we request comments on the feasibility of using this repository to provide support services for genetics studies, including cell line immortalization and DNA extraction. Scope The NIDDK currently estimates that there are more than 600,000 existing frozen samples including plasma, serum, urine, DNA and cell cultures that are stored in liquid nitrogen, at -70 C or at -20 C. In addition, there are several thousand existing frozen tissue samples. It is anticipated that over the next five years, future projects will generate more than 100,000 additional biosamples per year, including up to 1000 tissue samples, and that up to 20,000 new immortalized cell cultures will need to be produced from blood samples per year. Request The NIDDK seeks: a) To develop a source list of providers of one or more of the proposed services b) Comments on feasibility of performing the sample tasks on task list as a single contract. Can this acquisition be accomplished through a single contract awarded to a single contractor or should multiple contracts be awarded? Can one entity perform all these tasks? c) Comments on the scale of the proposed repository, given the large number of existing and future samples. Can a single entity process and store the number of samples projected for the repository? If not, what is the upper limit of samples that is feasible? d) Comments of organization of tasks. How should the tasks be structured for one or more contracts to maximize efficiency and minimize costs? Pre-solicitation meeting A meeting to discuss the proposed solicitation(s) will be held at ???? on ????. In advance of that meeting, please submit written responses to the requests and written questions that you plan to ask NIDDK representatives at the meeting using the following hyperlink: http://www.niddk.nih.gov/fund/repositories/form.htm After receipt and consideration of comments and suggestions received from interested parties in writing and at the meeting, the NIDDK will issue one or more Requests for Proposals to carry out the various tasks. Please note: All meeting proceedings and questions and answers submitted in writing, excluding proprietary information, will be posted at: http:// http://www.niddk.nih.gov/fund/repositories.htm Please address all inquiries about meeting logistics to: Please address all inquiries about the proposed contract to: Rebekah S. Rasooly, Ph.D., Division of Kidney, Urologic and Hematologic Disease, NIDDK, 301-594-6007, repositories@extra.niddk.nih.gov

Record

Loren Data Corp. 20011015/SPMSC001.HTM (W-284 SN5104T5)